Common Side Effects

While PQQ is generally safe for consumption, it may cause some minor side effects. These include headaches, drowsiness, and fatigue. However, these effects are typically mild and transient ^[1]. Unfortunately, the specific frequency of these side effects is not clearly mentioned in the available literature.

Rare but Serious Adverse Events

Although rare, serious adverse events can occur. In some animal studies, high doses of PQQ were associated with alterations in kidney function ^[4]. However, these findings are yet to be replicated in human studies, and further research is needed to establish a clear connection.

Drug and Supplement Interactions

Current research does not provide substantial evidence on potential drug interactions with PQQ. However, due to its antioxidant properties, it may theoretically interact with medications that also have antioxidant effects, affecting their overall effectiveness. It is always advisable to consult with a healthcare provider before starting any new supplement, especially if you are already on medication ^[1].

Who Should Avoid Supplements for Pqq?

While PQQ is generally safe for most adults, certain populations should exercise caution. Pregnant and breastfeeding women, for instance, should avoid PQQ supplements due to insufficient data on its safety during these periods ^[1]. Moreover, individuals with kidney disease may also need to avoid PQQ due to the possible alterations in kidney function observed in animal studies ^[4].

How to Minimize Side Effects

To minimize potential side effects of PQQ, start with a low dose and gradually increase it as tolerated. Always follow the manufacturer's instructions for dosage and frequency. Choosing a high-quality supplement that has undergone third-party testing can also help ensure safety and efficacy ^[5].

When to Consult a Healthcare Provider

It's essential to consult a healthcare provider if you experience persistent or severe side effects after taking PQQ. Signs of an allergic reaction, such as rash, itching, swelling, severe dizziness, or trouble breathing, also warrant immediate medical attention ^[1].

Conclusion

PQQ supplements offer potential health benefits, but like any supplement, they come with potential risks. Understanding these risks and taking necessary precautions can help ensure safe and effective use. Always consult with a healthcare provider before starting any new supplement, especially if you have existing health conditions or are currently taking other medications.

Remember, our symptom search tool is always available to help you monitor your health: Try the Symptom Search.

References

^[1] Yan T et al. (2024). Pyrroloquinoline Quinone (PQQ): Its impact on human health and potential benefits: PQQ: Human health impacts and benefits.. Curr Res Food Sci. PubMed: https://pubmed.ncbi.nlm.nih.gov/39513102/ ^[2] Shiojima Y et al. (2022). Effect of Dietary Pyrroloquinoline Quinone Disodium Salt on Cognitive Function in Healthy Volunteers: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study.. J Am Nutr Assoc. PubMed: https://pubmed.ncbi.nlm.nih.gov/34415830/ ^[3] Charrier D et al. (2024). Metabolic and Biochemical Effects of Pyrroloquinoline Quinone (PQQ) on Inflammation and Mitochondrial Dysfunction: Potential Health Benefits in Obesity and Future Perspectives.. Antioxidants (Basel). PubMed: https://pubmed.ncbi.nlm.nih.gov/39334686/ ^[4] Jonscher KR et al. (2017). Early PQQ supplementation has persistent long-term protective effects on developmental programming of hepatic lipotoxicity and inflammation in obese mice.. FASEB J. PubMed: https://pubmed.ncbi.nlm.nih.gov/28007783/ ^[5] Akagawa M, Nakano M, Ikemoto K (2016). Recent progress in studies on the health benefits of pyrroloquinoline quinone.. Biosci Biotechnol Biochem. PubMed: https://pubmed.ncbi.nlm.nih.gov/26168402/

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Disclaimer: This article is AI-generated for educational purposes only and is not a substitute for professional medical advice. Always consult with a healthcare provider before starting any supplement regimen.